Effect of alcoholic extract of shorea robusta gaertn f. resin on oxidative stress in streptozotocin-induced diabetic rats Kumawat Sanjay1, Verma Suman2, Singh W Ramdas1, Sadam Abdul1, Patel Madhuri1, Aneesha VA1, Madhu CL1, Singh Thakur U, Kumar Dinesh1,* 1Division of Pharmacology and Toxicology, IVRI, Izatnagar, Bareilly-243 122; 2Division of Bacteriology and Mycology, IVRI, Izatnagar, Bareilly-243 122, India *Corresponding author e-mail: dineshks17@gmail.com
Online published on 8 April, 2021. Abstract Oxidative stress associated with diabetes causes major microvascular complications, which led to a series of detrimental effects. Plant based polyphenols, most common flavonoids and phenolics are considered beneficial antioxidants in various chronic disease conditions. Ethanolic extract of Shorea robusta resin was analysed and found rich in flavonoid (418.83±26 mg QE/g) and phenol content (42.65±5.48 mg GAE/g). Administration of ethanolic extract of S. robusta restored the activities of SOD and catalase, but reduced the MDA and NO levels significantly (p<0.05) in diabetic rat serum. In conclusion, findings suggest antioxidant effect of S. robusta resin which may counter diabetes associated oxidative stress. Top Keywords Diabetes, Oxidative stress, Shorea robusta resin, Polyphenols. Top |