Antidiabetic effect of distilled cow urine in alloxan induced diabetic wistar rats Bhosle D.S.1, Ghumare B.C.2,*, Karande V.V.3, Dubey S.A.3, Rajurkar S.R.4, Mote C.S.5, Jadhav S.N.6 1M.V.Sc scholar, COVAS, Parbhani 2Assistant Professor, Pharmacology and Toxicology, COVAS, Parbhani 3Assistant Professor Pharmacology and Toxicology, COVAS, Parbhani 4Associate Professor, Pharmacology, COVAS, Parbhani 5Assistant Professor, Pathology, KNP Veterinary College, Shirwal, Satara 6Assistant Professor, Biochemistry, KNP Veterinary College, Shirwal, Satara *Corresponding author e-mail: bcghumare@gmail.com
Online published on 8 April, 2021. Abstract The sacred Indian cow, Bos indicus known as “Kamadhenu” in Indian scripts, is believed to be a “mobile hospital” for the treatment of many diseases. Though Indian Ayurvedic literature cites many medicinal properties of cow urine, there are limited scientific evidences to support this. Earlier studies have revealed the presence of antioxidants and free radical scavengers in cow urine which might be responsible for the observed antidiabetic effects. Hence, the present study of the antidiabetic activity of distilled cow urine was undertaken. The effect of cow urine distillate was studied in vivo in rats administered with Alloxan. Diabetes was induced by administration of single dose of Alloxan (120 mg/kg body wt., IP) dissolved in sterile normal saline. The antidiabetic effect of the cow urine distillate (three different doses) and a standard drug, Glibanclamide (0.25 mg/kg, PO.) was studied in these diabetic rats. The parameters used in the study included assessment of blood glucose levelsand biochemical parameters. The cow urine distillate produced a significant (P<0.05) reduction of the elevated blood glucose, serum cholesterol, serum triglycerides, AST, ALT levels when compared with the diabetic control and was comparable with standard drug. Diabetic animals treated with cow urine distillate showed significant lowering of blood glucose levels. Top Keywords Antidiabetic, Cow urine distillate, Alloxan, Glibenclamide. Top |