|
|
(18.190.153.63)
|
Users online: 4255
|
|
|
|
|
|
Ijournet
|
|
|
|
|
Analytical method development and validation for the estimation of Rilpivirine and its N-Oxide impurity using UPLC Soujanya Varada, Nalanda Revu Baby* Department of Pharmaceutical Analysis, GITAM School of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, India *Corresponding Author E-mail: nrevu@gitam.edu
Online Published on 07 February, 2024. Abstract Rilpivirine is used to treat human immunodeficiency virus type 1 (HIV-1). A new stability indicating RP-UPLC method has been developed for the estimation of Rilpivirine and N-Oxide impurity using Waters UPLC Aqcuity SYSTEM with TUV detector integrated with Empower 2 Software with Kromasil (250 × 4.6 mm, 5μm) C18 column (PDA detector) was used for the present study. A mixture of 0.1% ortho phosphoric acid solution and methanol (50: 50, v/v) was used as the mobile phase for the chromatographic study (Flow rate: 1.0 ml/min; Detection wavelength: 279 nm). Stress degradation studies were performed and the method was validated as per ICH guidelines. Top Keywords Rilpivirine, RP-UPLC, N-Oxide, Stability indicating, Validation, ICH guidelines. Top | |
|
|
|
|
║ Site map
║
Privacy Policy ║ Copyright ║ Terms & Conditions ║
|
|
749,174,180 visitor(s) since 30th May, 2005.
|
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
|
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.
|