Development of Oral Mucoadhesive Tablets of Terbutaline Sulphate Using Some Natural Materials Extracted from Albelmoschus esculeatus and Tamarindus indica Chanda Ranabir1,*, Mahapatro S. K.1, Mitra Tutun1, Roy Amit2, Bahadur Sanjib2 1Himalayan Pharmacy Institute, Majhitar, Rangpo, E. Sikkim-737136, India 2GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone-451228, M.P *Corresponding Author E-mail: ranabirchanda@yahoo.com
Abstract Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Several synthetic polymers are in use for this purpose. Since the biodegradability of the synthetic polymers are questionable, in this investigation an oral mucoadhesive controlled delivery system has been developed for terbutaline sulphate using natural mucoadhesive materials extracted from edible fruits like Albelmoschus esculeatus and Tamarindus indica that have better mucoadhesive property than synthetic polymer carbopol 934. The in-vitro adhesive and mucoadhesive strength and swelling property of mucoadhesive materials extracted from edible fruits of Albelmoschus esculeatus and Tamarindus indica were evaluated and compared with Carbopol 934 by Share Stress and Park and Robinson methods. Different formulations of oral mucoadhesive coated terbutaline sulphate tablets were prepared using these natural materials and carbopol 934 and hardness, thickness, friability, weight variation and assay of tablets were tested. The in-vitro release of terbutaline sulphate was studied in buffer pH 7.2 at 37°C± 0.5°C. The blood plasma concentration of terbutaline sulphate in rabbits was determined using HPLC. It was found that mucoadhesive materials extracted from edible fruits of Albelmoschus esculeatus and Tamarindus indica exhibited better adhesiveness and mucoadhesiveness as compared with the synthetic mucoadhesive agent Carbopol 934 by different methods. The in-vitro and in-vivo drug release study of terbutaline sulphate exhibited extended drug release profile for tablets prepared with natural materials than synthetic polymers. After in-vitro and in-vivo correlation study it was seen that both in-vitro and in-vivo drug release study showed the same release profile. The present study shows that natural mucoadhesive materials extracted from edible fruits of Albelmoschus esculeatus and Tamarindus indica have greater mucoadhesive property than synthetic polymer i.e. Carbopol 934 where both are used in the same amount. Top Keywords Mucoadhesive, Terbutaline sulphate, Tablets. Top |