Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology Suryawanshi CP1,*, Patil VR1, Chaudhari RY1, Kale MK3, Firake SD3, Pimprikar RB2, Patil MD2, Yeshwante SB2, Saindanem DS2 1Tapi Valley Education Society's Hon. L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS) 2Nagaon Education Society's Gangamai College of Pharmacy, Nagaon-424005, Dist Dhule (MS) 3K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon-425201 *Corresponding Author: Suryawanshi CP Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS) Tel-9423173174 Email: pimprirb@rediffmail.com
Online published on 20 March, 2013. Abstract The Parkinson's disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson's symptoms like, tremor, salivation and temperature variation. Hence Oxotremorineinduced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson's symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson's symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson's disease. Top Keywords Parkinson's disease, oxotremorine, tremor, procyclidine. Top |