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Pharmacokinetics of toltrazuril following single dose administration in poultry Bisht Kamini, Ahmad A.H.*, Pant Disha Department of Pharmacology & Toxicology, College of Veterinary & Animal Sciences, G. B. Pant University of Agriculture and Technology, Pantnagar - 263145, India *corresponding author: ahahmadpharma@gmail.com
Online published on 8 April, 2021. Abstract The present study was undertaken to investigate the pharmacokinetics of Toltrazuril in poultry following single dose (7mg.kg-1) oral administration. The concentration of Toltrazuril in plasma was analysed by High Performance Liquid Chromatography (HPLC). The maximum plasma concentration (Cmax ) of 3.383 μg.ml-1 was obtained. The time to reach Cmax (Tmax) was 0.28 days (6.72 h) post administration. The volume of distribution (Vd), elimination half life (Beta_HL) and area under curve (AUC) were calculated as 1908.93 ml.kg-1, 2.30 days, 10.57 day.μg.ml-1, respectively. It can be concluded from the study that a priming dose of 7.0 mg.kg-1 with a maintenance dose of 2.5 mg.kg-1 at every 14 day is recommended in poultry. Top Keywords Pharmacokinetics, Toltrazuril, High performance liquid chromatography. Top | |
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