Journal of Innovation in Pharmaceutical Sciences
Year : 2017, Volume : 1, Issue : 1
First page : ( 1) Last page : ( 5)
Online ISSN : 2581-5695.

A Comparative Evaluation of anti-ulcer activity of plant Leucas aspera spreng. & Caesalpinia crista linn. seeds in albino rats

Gupta Nakul*, Safhi Mohammed M., Nomier Yousra, Agarwal Meetu

Department of Pharmacology, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia

*E-Mail: drnakulmgupta76@gmail.com

Online published on 27 September, 2019.

Abstract

To compare the anti-ulcer activity of extracts of plant Leucas aspera spreng. and seeds of Caesalpinia crista linn. by pylorus ligation induced gastric lesions in albino rats. 36 adult albino rats of either sex were distributed in six groups (n=6) in each model. Extracts of plant Leucas aspera spreng. and seeds of Caesalpinia crista linn. were evaluated for anti-ulcer activity by using pylorus ligation induced ulcer models in experimental animals. Ranitidine (20mg/kg ip) was used as a standard drug. The percentage yield of ethanolic extracts was found to be 8.7% for C. crista and 6.2% for L. aspera. Pretreatment with ethanolic extracts of plant L. aspera & seeds of C. crista significantly reduced the volume of gastric secretions, total acidity, free acidity, and elevated pH of the gastric fluid in a dose dependentmanner, but the maximum benefit was observed by the ethanolic extracts of C. crista at a dose level of 200mg/kg body weight. Similarly protection against ulcers was offered by the both test extracts but maximum percentage inhibition of ulceration was given by C. crista. The standard drug used was ranitidine at a dose level of 20 mg/kg body weight. It can be concluded that the ethanolic extracts of plant L. aspera and seeds of C. crista. have anti-ulcer effect, but extract with more ulcer protection belongs to seeds of C. crista.

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Keywords

Leucas aspera, Caesalpinia crista, Antiulcer.

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