Amelioration of hyperlipidemia and coronary risk markers with supplementation of Cinnamomum zeylanicum bark extracts on Triton WR-1339 induced hyperlipidemia in Wistar albino rats Kadali S. L. D. V. Ramana Murty1, Gupatha B. H. M. R. K.2,*, Kumar M. Vijay3, Revanasiddappa B. C.4 1Assistant Professor, Dept. of Pharmacology, Modern Institute of Medical Sciences, Indore, Madhya Pradesh 2Assistant Professor, Dept. of Pharmacology, IQ City Medical College, Durgapur, West Bengal 3Assistant Professor, Dept. of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Mangalore, Karnataka, India 4Associate Professor, Dept. of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Mangalore, Karnataka, India *Corresponding Author: Email: manikanta05bayya@gmail.com
Online published on 3 January, 2019. Abstract Introduction Cinnamomum zeylanicum bark used in Indian traditional medicine to treat hyperlipidemia and cardiovascular diseases. Hyperlipidemia is a major risk factor for coronary heart disease and metabolic syndrome. Objective The present study was to evaluate the antihyperlipidemic effect of ethanolic and aqueous extracts of Cinnamomum zeylanicum bark against Triton induced hyperlipidemia in Wistar albino rats. Materials and Methods Thirty rats (200-230gm) were randomly divided into five groups of six rats in each, received standard diet and water daily. Normal control (5% CMC), positive control (Triton 400mg/kg), standard control (atorvastatin 40mg/kg), ethanolic and aqueous extracts of Cinnamon groups (CZEE and CZAE 500 mg/kg of each) were assigned and treated respectively. All the groups except normal control were administered triton to induce hyperlipidemia. Both the standard and plant extracts were administered for seven days orally. At the end of the study, fasting blood was collected and serum was separated out to estimate the lipid profile and various markers of coronary heart diseases. Results Post supplementation of atorvastatin, CZEE and CZAE significantly (P<0.05) ameliorated the hyperlipidemia and decreased the risk of cardiovascular diseases in triton induced hyperlipidemic rats. Conclusion From the observations, it can be concluded that supplementation of Cinnamon extracts can significantly decline the lipid abnormalities and ameliorate the markers of coronary heart disease and provides the scientific evidence for their traditional claims. Further molecular studies are warranted to evaluate the causative molecule for antihyperlipidemic effect. Top Keywords Hyperlipidemia, Cardiovascular diseases, Triton, Atorvastatin and Cinnamon extracts. Top |