Comparative study of therapeutic efficacy of intralesional vitamin D3 versus intralesional purified protein derivative in the treatment of warts Akula Madhavi Latha1,*, Shetty Monisha2, Shetty Vinma3, Patel Parag4, Basil Ameen5 1Final Year PG, Dept. of Dermatology, Venereology and Leprosy, AJ Institute of Medical Sciences, Mangalore RGUHS, Karnataka, India 2Final Year PG, Dept. of Dermatology, Venereology and Leprosy, AJ Institute of Medical Sciences, Mangalore RGUHS, Karnataka, India 3Associate Professor, Dept. of Dermatology, Venereology and Leprosy, AJ Institute of Medical Sciences, Mangalore RGUHS, Karnataka, India 4M.D Dermatology, Dept. of Dermatology, Venereology and Leprosy, AJ Institute of Medical Sciences, Mangalore, RGUHS, Karnataka, India 5Final Year PG, Dept. of Dermatology, Venereology and Leprosy, AJ Institute of Medical Sciences, Mangalore, RGUHS, Karnataka, India *Corresponding Author: Email: madhu9madhavi@gmail.com
Online published on 14 January, 2019. Abstract Introduction Warts are benign epidermal proliferations of skin and mucosa caused by human papilloma virus. Destructive therapeutic modalities are limited by cost, pain, scarring. Immunotherapy is a new modality which acts on enhancing cell mediated immunity. Objective This study aims to evaluate and compare efficacy of intralesional vitamin D3 and purified protein derivative (PPD) in treatment of warts. Materials and Methods It is a prospective hospital based comparative study among 40 patients with warts. Patients were randomly and equally divided. Group A patients were given intralesional vitamin D3 (0.2ml of 15mg/ml into each wart) and Group B patients were given intralesional PPD (0.2ml of 5TU/ml into each wart). The injections were repeated every 2 weeks until complete clearance. Decrease in size and number of lesions were evaluated and photographic record was maintained. Patients were followed up after 3 months. Unpaired t test was used for statistical analysis. Results The study found that 14 out of 20 patients (70%) of Group A showed complete response after 4 sessions and 6 patients (30%) showed moderate response. 17 out of 20 patients (85%) of Group B showed complete response, 2 patients (10%) showed moderate response, 1 patient (5%) showed no response. Recurrence was observed in 1 patient after 3 months who received vitamin D3. No serious adverse effects were observed. Conclusion Both vitamin D3 and PPD showed positive results with PPD having faster and better efficacy in treatment of multiple common warts. Top Keywords Immunotherapy, Warts, Intralesional, Vitamin D3, Tuberculin purified protein derivative. Top |