Clinical and microbiological profile of skin and soft tissue infections (SSTI) leading to sepsis Lakhani Som Jitendra1,*, Khara Radhika2, Lakhani Sucheta Jitendra3, Shah Chaitri4, Lakhani Jitendra D.5 1Assistant Professor, Dept. of Dermatology, SBKS Medical Institute & Research Centre and Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India 2Associate Professor, Dept. of Microbiology, SBKS Medical Institute & Research Centre and Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India 3Professor, Dept. of Microbiology, SBKS Medical Institute & Research Centre and Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India 4Professor, ICU In-charge and Assistant Superintendent, Dept. of Anaesthesia, SBKS Medical Institute & Research Centre and Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India 5Professor and Academic Director, Dept. of Medicine, SBKS Medical Institute & Research Centre and Dhiraj Hospital, Sumandeep Vidyapeeth, Piparia, Vadodara, Gujarat, India *Corresponding Author: Email: somlakhani24@gmail.com
Online published on 14 January, 2019. Abstract Preamble Skin and soft tissue infections (SSTI) are an important cause of sepsis. Acute skin failure may result from many dermatological conditions. In this study we tried to highlight the role of skin failure as a component of multiple organ dysfunctions. Materials and Methods All adult patients (>18 years) diagnosed clinically as sepsis due to skin and soft tissue infections were included. Risk assessment was done using various parameters. Identification of pathogens and their antibiotic sensitivity pattern was performed by blood and skin swab cultures. Results A total of 55 patients (31 male and 24 female) were included in the study. The common causes of SSTI were surgical site infections, cellulites, necrotisingfasciitis, traumatic open wounds, Toxic epidermal necrolysis, acute generalized exanthematous pustulosis, burns, bed-sores, unknown wounds and others. The major risk factors identified were the percentage of skin involvement, depth of wounds, presence of unhealthy granulation tissue and co morbidities like diabetes and immunodeficiency. MRSA and ESBL producing gram negative bacteria were important causative microbes for SSTI induced sepsis. Conclusion SSTI is one of the important causes of sepsis. Early recognition and management of risk factors can prevent adverse outcome. Knowing microbiological etiology and drug sensitivity pattern is important is connection with SSTI related sepsis. Septic shock was identified as most important organ failure on admission leading to death in patients having SSTI related sepsis. Top Keywords Skin and Soft tissue infections (SSTI), Multiple organ dysfunction syndrome, Risk factors, SCORTEN. Top |