Does isotretinoin (ISO) Therapy Increase Coagulation Tendency? Evaluation of MPV values and MPV/platelet rate Ozuguz Pinar1,*, Ulu M. Sena2, Kacar Seval Dogruk1, Ozuguz Ufuk3, Karaca Semsettin1 1Department of Dermatology, Izmir Katip Celebi University, Turkey 2Department of Nephrology, Afyon Kocatepe University, Turkey 3Department of Endocrinology, Afyon Kocatepe University, Turkey *Corresponding Author: Email: pozoguz@gmail.com
Online published on 3 March, 2016. Abstract Introduction/Purpose Mean Platelet Volume (MPV), an indicator of platelet activation, is a new risk factor for atherothrombosis and an important marker for the increase in thromboembolic diseases. MPV/platelet ratio is considered as a risk factor for various diseases such as myocardial infarction. In this study, we aimed to investigate the possible effect of ISO on blood cell counts especially MPV and MPV/platelet ratio. Materials and Methods 75 patients, between the ages of 18–25 with moderate or severe acne vulgaris and using oral isotretinoin (0.5 mg/kg) were included in the study. Platelet count and MPV values of patients (pre-treatment and 3 months after the treatment) were recorded retrospectively. Results The mean age of patients was 23.32±3.44 years. 40 patients were female and 35 were male. MPV levels and MPV/p ratio of “before treatment period” were significantly higher than the “after treatment period” (p<0.001). Conclusion In the literature, alteration in platelet levels under ISO treatment is a controversial issue. Furthermore, it was emphasized that, ISO treatment may be change platelet functions. In our study, MPV values and MPV/p ratio were decreased after ISO treatment. Our data indicates that, the thromboembolic risk of patients with acne vulgaris may reduce after ISO treatment. Top Keywords Acne vulgaris, Isotretinoin, MPV, Platelet, Thromboembolism risk. Top |