Assessment of maternal vitamin D status in gestational diabetes mellitus Kalpanarani U. Assistant Professor, Dept. of Physiology, Govt. Theni Medical College, Theni, Tamil Nadu Email: varshrosh10@gmail.com Online published on 23 February, 2018. Abstract Introduction Gestational Diabetes Mellitus is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. Recently it has been discovered that vitamin D plays a major role in glucose homeostasis. Studies have also reported that vitamin D deficiency may increase the risk of GDM. Aim To assess the maternal vitamin D status in women with GDM and to compare the levels of vitamin D in women with GDM and normal pregnancy. Materials and Method A total of 100 pregnant women during 24 to 28 weeks of pregnancy between the age group of 20 to 35 years and BMI of 18.5 to 29.99 kg/m2 were selected. Fifty women diagnosed having GDM by 75 gm OGTT with the blood sugar levels of > 140 mg/dl after 2 hours of oral glucose according to WHO criteria were taken as GDM group and 50 women with normal OGTT values as control group. The total Serum 25(OH)D levels were estimated by fully automated chemi luminescence immunoassay. The results were analyzed by chi square test and Student's ‘t’ test. A p value of <0.05 is considered significant. Results The mean vitamin D level was significantly decreased in women with GDM (11.78±7.86ng/ml) compared to normal pregnancy (31.48±5.01ng/ml) with p value <0.0001 and is found to be significant. Conclusion Vitamin D levels were found to be lower in women with GDM as compared to women with normal pregnancy. As the vitamin D level decreases, the blood sugar level increases in women with GDM. Top Keywords Gestational Diabetes Mellitus, Vitamin D, Oral Glucose Tolerance Test, Chemi luminescence Immunoassay. Top |