Asian Journal of Research in Pharmaceutical Science
Year : 2011, Volume : 1, Issue : 1
First page : ( 26) Last page : ( 28)
Print ISSN : 2231-5640. Online ISSN : 2231-5659.

Development and Study of Wound Healing Activity of an Ayurvedic Formulation

Rawat Swati^1,*, Gupta Akhilesh²

¹Shri Bhagwan College of Pharmacy, Aurangabad (M.S.)

²Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.)

*Corresponding Author E-mail: swati_r@k.st

Online published on 5 June, 2014.

Abstract

The effect of prepared Ayurvedic formulation was evaluated on excision and incision wound models in rats. The wound-healing activity was assessed by the rate of period of epithelialization and skin-breaking strength. Histological study of the granulation tissue was carried out to know the extent of collagen formation in the wound tissue. The Ayurvedic formulation prepared was then promoted for wound-healing activity in two wound models. The treated animals showed significant reduction in the wound area up to (P<0.001) and faster rate of epithialisation (23.17±0.54). In an incision wound model, formulation treated animals demonstrated significant skin-breaking strength up to 420.33±5.92. Histological studies of the tissue obtained from the formulation treated group revealed that the activity was more significant in this group. Our present study reveals that the Ayurvedic formulation posses potent wound healing activity, which could be a good choice of remedy for wound healing but less potent than standard Nitrofurazone.

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Keywords

Excision wound, incision wound model, Ayurvedic medicinal plants.

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