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Simultaneous Estimation of Nebivolol and Hydrochlorothiazide in Combined Tablet Dosage Form by Multicomponent Mode of Analysis Tarte PS*, Wate SP, Khedikar PB, Satpure BT, Pawnikar G Sharad Pawar College of Pharmacy, Wanadongari, Hingana Road, Nagpur-441110 (M.S.) *Corresponding Author E-mail: pawantarte@rediffmail.com
Online published on 13 March, 2013. Abstract A simple, accurate, precise and economical procedure for simultaneous estimation of Nebivolol hydrochloride and Hydrochlorothiazide in two component tablet dosage form has been developed utilizing concept of standard addition. The method is based upon determination of Nebivolol at 281 nm and Hydrochlorothiazide at 272 nm, in aqueous methanol (20% v/v). Nebivolol hydrochloride and Hydrochlorothiazide at their respective λmax 281.0 nm and 272.0 nm shows linearity in the concentration range of 5–35 μg/ml and 10–70 μg/ml respectively. The method was validated statistically. Recovery study was performed to confirm the accuracy of the method. Top Keywords Nebivolol hydrochloride, Hydrochlorothiazide, simultaneous estimation. Top | |
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