Spectrophotometric Methods for Simultaneous Estimation of Rabeprazole and Diclofenac from Combined Tablet Dosage Form Lohe RW1,*, Suruse PB1, Kale MK1, Barethiya PR2, Kasture AV2, Lohe SW3 1Kamla Nehru College of Pharmacy, Butibori, Nagpur-441108 (MS) India 2Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha- 442001 (MS) India 3Anurag College of Pharmacy, Warthi, Bhandara (MS) India *Corresponding Author E-mail: riteshlohe1982@gmail.com
Online published on 13 March, 2013. Abstract Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of Rabeprazole and Diclofenac in combined tablet dosage form have been developed. The first developed method employs formation and solving of simultaneous equation using two wavelengths 294.0 nm and 281.2 nm for formation of simultaneous equation. Second developed method involves graphical absorbance ratio, using two wavelengths. Both of these methods obey Beer's law in the employed concentration ranges for respective methods. Results of analysis were validated statistically and by recovery studies. Top Keywords Spectrophotometric estimation, Rabeprazole, Diclofenac. Top |