Asian Journal of Research in Chemistry
Year : 2008, Volume : 1, Issue : 1
First page : ( 1) Last page : ( 8)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Deoxycholic Acid: A Review

Tripathi Kishu^1,, Kulshreshtha Shobha²

¹Surya College of Pharmacy, Lucknow

²Department of Pharmacology, SN Medical College, Agra

Online published on 13 March, 2013.

Abstract

Inhibiting 11HSD2;mediate cortisol-dependent nuclear translocation and transcriptional activation of MR and are responsible at least for a part of the sodium retention and potassium excretion observed in patients with biliary obstruction;dose-dependent scratching of the injected site with the forepaws and hindpaws. Up to 100 μg of sodium deoxycholic acid, deoxycholic acid induced intestinal secretion in part by lowering mucosal permeability; DCA decreased adhesion of HCA-7 cells to the substratum and induced dephosphorylation of FAK at Tyrosine-576/577 (Tyr-576/577) and Tyr-925; inhibition of Clostridium botulinum, hyperproliferation of colonic crypt cells with an expansion of the proliferative zone,which is regarded as a biomarker of increased cancer risk; significantly increase tyrosine phosphorylation of catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness, major impact on apoptotic mechanisms in colonic cells and this may be contributing to its effect as a tumor promoter.

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Keywords

Deoxycholic acid.

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