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An Efficient Synthesis of Rabeprazole Sodium Jadhav Ramchandra, More Kishor, Khandekar Dileep, Yamgar Ramesh, Sawant Sudhir* Chemistry Research Laboratory, Patkar Varde College, Goregaon (West), Mumbai 400 062, India *Corresponding Author E-mail: sawantsudhir@hotmail.com
Online published on 19 June, 2014. Abstract This paper deals with an efficient preparation of 2-Chloromethyl pyridine intermediate useful for preparation of pyridinylmethyl sulphinyl benzimidazole especially Rabeprazole sodium. In the present study, we have demonstrated a shorter route of synthesis for 2-Chloromethyl pyridine intermediate and in situ condensation with 2-Mercaptobenzimidazole to get Rabeprazole. This strategy is extremely advantageous from the commercial scale up point and would help in reducing the overall timeline and cost for the large scale manufacture of Rabeprazole sodium. Top Keywords Proton pump inhibitors (PPI), 2-Chloromethyl pyridine intermediate, Rabeprazole sodium. Top | |
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