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Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form Rajendran S.S.*, Santhi N., Kumar Nallasivan P., Sam Solomon W.D., Narayanan R. Venkata RVS College of Pharmaceutical Sciences, Sulur, Coimbatore *Corresponding Author E-mail: ss.rajendra00@gmail.com
Online published on 19 June, 2014. Abstract Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous estimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (isoabsorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5–25 μg/ml for Cefixime and 2–10 μg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory. Top Keywords Cefixime, Ofloxacin, Simultaneous equations, Absorbance ratio method. Top | |
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