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Spectrophotometric Estimation of Ziprasidone in Bulk and In Pharmaceutical Formulations Deepthi N. Santhi Ch.*, Rajendran S.S., Gananadhamu S., Rao G. Devala, Lohit Sai K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada *Corresponding Author E-mail: santhi.sanu@gmail.com
Online published on 19 June, 2014. Abstract A new simple, sensitive and precise visible spectrophotometric method has been developed for the determination of ziprasidone in bulk and in pharmaceutical formulations. This method is based on the hydrolysis of Ziprasidone, followed by diazotization and coupling with N-(1-naphthyl) ethylene diamine dihydrochloride to form an azo dye which was estimated at an absorption maximum of 540nm (pink color). This method has the linearity in the concentration range of 2–10μg/ml. This method is statistically evaluated for efficacy. Top | |
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