Comparative Study on Effect of Misoprostol and Oxytocin in the Active Management of Third Stage of Labor in A Tertiary Hospital in Manipur, India Roy Rajib1,*, Vernekar Manisha2 1Assistant Professor, Dept. of Obstetrics & Gynecology, ESI-PGIMSR, ESI-MC & Hosp, Joka, Kolkata, W.B 2Senior Resident, Dept. of Obstetrics & Gynecology, ESI-PGIMSR, ESI-MC & Hosp, Joka, Kolkata, W.B *Corresponding author: Rajib Roy, Assistant Professor Dept. of Obst & Gyne, ESI-PGIMSR, ESI-MC & Hosp., Joka, Kolkata Address: Plot No 34/1, Phase I, Pailan Park Housing Project, Pailan Park, Kolkata, W.B., 700104
Online published on 15 December, 2017. Abstract Background Hemorrhage of pregnancy is the leading cause of maternal deaths in the developing world, responsible for 25% of all global maternal deaths. Worldwide 125, 000 women (out of an estimated 0.5 million maternal deaths) die due to obstetric Post-partum hemorrhage each year (WHO 1999). Aims and Objects The prospective randomized comparative study was carried out to compare the effectivity of oral misoprostol versus oxytocin in the active management of third stage of labor in the dept. of obstetrics and gynecology, RIMS, Imphal from September 2008 to August 2009. Method Sample of 200 parturient women was divided into study and control group, each group consisting of 100 women. Oral misoprostol 400 microgram and 10 IU oxytocin intramuscularly was allocated randomly among the subjects. Blood loss, any bleeding within the first 24 hours after delivery, maternal hemoglobin or hematocrit concentration pre and post-delivery, occurrence of side effects were noted. Data was entered in SPSS 16 and analyzed using mean, Chi square-test and comparison was made between groups by independent t-test. The study was conducted after the approval from the Institutional Ethical Committee. Results Insignificant P= 0.776 highlights that there is no variation of spontaneous vaginal delivery between the groups of women who received misoprostol and the group who received oxytocin. An interesting finding is observed in the table that those who received misoprostol has less percentage of post-partum hemorrhage in comparison with the corresponding percentage of those who received oxytocin. Only 3% of the women who received misoprostol required additional uterotonic. Regarding the side effect, the study group has more percentage i.e., 13% than that of control group (9%). This suggests that there is no significant difference in change in hemoglobin concentration between the two groups. Conclusion Oral misoprostol is a potent, effective and stable uterotonic with a rapid onset of action. It is as effective as standard oxytocic drugs (like oxytocin and methergin) in preventing atonic postpartum hemorrhage. Top Keywords Post-Partum Hemorrhage, Misoprostol, Oxytocin, Active Management of Third Stage of Labor. Top |