To Evaluate Diagnostic Utility of FNAC for Palpable Thyroid Lesion and Comparison with Ultrasound and Thyroid Profile Singh Guddi Rani1,*, Singh Krishna K2, Kumar Ajeet3, Singh Sangita4, Prasad Umakant5, Kumar Bipin6 1Senior Resident of, Pathology 2Assistant Professor of, Psychiatry 3Senior Resident of, Pathology, IGIMS, Patna, Bihar, India 4Assist. Professor of, Pathology, Saraswathi Medical College, Hapur, U.P, India 5Assistant Professor of, Radiology 6Professor of, Pathology, IGIMS, Patna, Bihar, India *Corresponding author: Dr. Guddi Rani Singh Senior Resident, Dept. of Pathology, IGIMS, Patna, Bihar, India, Email: drgrsinghpatho@gmail.com
Online published on 18 July, 2017. Abstract Objective To study the advantage of FNAC over ultrasound finding in thyroid lumps by comparing the diagnostic accuracy in term of sensitivity, specificity, positive and negative predictive values considering the histopathological diagnosis of thyroidectomy specimen(either total/subtotal/partial) specimen as the gold standard. Material and method A prospective study of 64 patients with thyroid lump was conducted in the Department of Pathology of tertiary care teaching hospital of northern part of India. All the patients with palpable thyroid lump were randomly selected, irrespective of their age, religion, marital status, occupation or social status for FNAC and USG thyroid following a thorough clinical check-up during the period of January 2015 to February 2016 were included. All of these patients were followed with thyroidectomy with subsequent histopathological findings. Results Results of FNAC thyroid and USG Thyroid were reported according to standard reporting format And then their results were compared with each other in term of sensitivity, specificity, positive and negative predictive values considering the histopathological diagnosis of thyroidectomy specimen (either total/subtotal/partial) specimen as the gold standard. Sensitivity of FNAC was 92.1875 & Sensitivity of USG was 85.9375; Specificity of FNAC in diagnosing malignant lesion was 100%. Specificity of USG in diagnosing malignant lesion was 100%; Positive Predictive Value for FNAC was 100%; Positive Predictive value for USGwas 100%; Negative Predictive Value for FNAC was 94.545% and Negative Predictive Value for USG was 90.909%. Conclusion In the present study, we had concluded that FNACis found to be the most useful line of investigation than other investigations like ultrasonography (USG), and thyroid function test (TFT). Top Keywords Fine Needle Aspiration Cytology (FNAC), USG, First-line diagnostic, Sensitivity, Specificity, Positive Predictive Value and Negative Predictive Value. Top |