The Potential Toxic Effect of Anabolic Androgenic Steroids on the Endocrinal System of Male Athletes Abdelwahab Dalia Hassan1, Ghaleb Sherien S.2, Abdelhamed Ibrahem G A1,*, Abelaleem Mostafa A1 1Forensic medicine and clinical toxicology department, Faculty of medicine, Beni-Suef University, Beni-Suef, 62514Egypt 2Forensic medicine and clinical toxicology department, Faculty of medicine, Cairo University, Cairo, 11865, Egypt *Corresponding Author, Dr. Ibrahem G A Abdelhamed, Department of Forensic medicine and clinical, Faculty of Medicine, Beni Suef University, Beni-Suef, 62514Egypt, E-mail: gibrahem091@gmail.com
Online Published on 12 January, 2024. Abstract Background Anabolic steroids are currently utilized not just in accordance with medicinal indications, but also as a doping drug in sports or recreational exercisers. After widespread application of them, a variety of adverse effects became apparent. Objective The purpose of this study was to investigate the toxic effects of chronic use of Anabolic Androgenic Steroids from non-identified sources on endocrinal system of male athletes. Methods The research was conducted on three different groups of athletic participants: Group (A) served as a control, Group (B) received anabolic androgenic steroids at a high dose of 400 mg/ml, and Group (C) received anabolic androgenic steroids at a low dose of 250 mg/ml. Three different groups have each had their testicles imaged using ultrasonography. In addition, levels of FSH and LH have been tested. Results The mean age was 25.04±2.75 in control group, 24.78±3.15 in low dose anabolic androgenic steroids, 24.37±3.88 in high dose anabolic androgenic steroids, with no statistical significant difference. The mean body mass index was 27.65±2.58 in control group, 27.58±2.37 in low dose anabolic androgenic steroids, 28.34±3.28 in high dose anabolic androgenic steroids, with no statistical significant difference. There was a statistically significant difference between the control group and AS groups regarding the serum FSH levels, while there was no significant difference between both groups of AS (low dose and high dose). FSH was significantly higher in control group. There were statistically significant differences between the control group and AS groups regarding the serum LH levels, while there is no significant difference between both groups of AS (low dose and high dose). LH was significantly higher in control group. There was a statistically significant difference between the three groups regarding left testicular volume. The smaller in volume were seen in group C, while there were no significant differences between the three groups regarding right testicular volume. Conclusions Anabolic androgenic steroids affected male endocrinal function of athletes negatively and medical observation and hormonal follow up is essential. Top Keywords Anabolic steroids, Doping drugs, Testicular ultrasonography. Top |