Effects of Passiflora edulis var. flavicarpa on liver functional parameters in alloxan induced diabetic mice Holidah Diana1, Dewi Ika Puspita1,,2,,*, Pusparini Dyah1, Rochayati Diva1, Nurrizki Azharia M.1 1Preclinical Pharmacology Research Group, Faculty of Pharmacy, Universitas Jember, Jl Kalimantan I/2, Jember, 68121, East Java, Indonesia 2Drug Utilization and Discovery Research Group, Faculty of Pharmacy, Universitas Jember, Jl Kalimantan I/2 Jember, 68121, Jember, East Java, Indonesia *Corresponding author e-mail: ikapdewi@unej.ac.id
Online published on 23 September, 2021. Abstract Uncontrolled diabetes mellitus type 2 can lead to severe impairment to organs such as the heart, blood vessels, eyes, kidneys, and nerves which caused complications such as cardiovascular disease. Passion fruit (Passiflora edulis) is rich in phytochemicals, including flavonoids, triterpenoids, and carotenoids. The fruit of this plant has many pharmacological activities. One of the varieties was P. edulis var. flavicarpa showed antioxidant activity in vitro and antidiabetic in vivo in its leaves and stems. The benefits of this fruit in liver disorders associated with diabetes have not been inspected. This research was planned to study the effects of P. edulis var. flavicarpa on liver functional parameters and oxidative stress level in alloxan-induced diabetic mice. Six groups of Balb-C strain male mice consist of normal group, diabetic group, metformin group, and yellow passion fruit group with dose 40, 50, and 60 mL/kg were treated for 14 days. The diabetic effect was induced by alloxan on all groups except normal. On the 1st and 15th day of the treatment, the aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol, and triglyceride levels were measured. The malondialdehyde (MDA) level as oxidative stress parameter was measured only on the 15th day. This study showed that the P. edulis var. flavicarpa decreased the AST, ALT, total cholesterol, and triglyceride levels. The MDA level of the P. edulis var. flavicarpa treatment groups were significantly different from the diabetic group. The best activity was achieved at dose of 60 mL/kg. Our results suggests the P. edulis var. flavicarpa fruit improved liver functional and oxidative stress parameters in alloxan-induced diabetic mice. Top Keywords Passion fruit, ALT, AST, Cholesterol, Diabetes mellitus, Triglyceride, Oxidative stress. Top |