Endometrial carcinoma in a rabbit - a case report Parmar R.S.2,*, Raval S.H.2, Patel J.G.2, Srivastava A.K.1,2, Joshi H.R.2, Mithapirji R.M.2, Patel B.J.2, Joshi D.V.2 2Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India 1Department of Livestock Production and Management, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India *Corresponding author: e-mail: drrohit.vet23@gmail.com
Abstract A carcass of nearly 7 year old intact female New Zealand White rabbit was presented for postmortem examination. On necropsy, both uterine horns were gray to black, markedly thickened, multinodular and occupied almost 35 to 40% space of abdominal cavity. Neoplastic nodules were soft and gray to black. Multinodular/polypoid coalescing masses were noted in uterine lumen. Neoplasm was metastasised to lungs and wall of thoracic cavity. On microscopic examination, moderately cellular neoplasm composed of polygonal cells that arranged in tubules or acini and separated by variably dense fibrovascular stroma. Within the neoplasm there were focal extensive to multifocal large areas of necrosis, hemorrhages and infiltration of inflammatory cells. Microscopically, metastasized neoplasm in lungs and thoracic wall showed similar histopathology. On the basis of histopathology, this neoplasm was diagnosed as endometrial carcinoma. Top Keywords Rabbit, Endometrial carcinoma, Pulmonary metastasis. Top |
Figures | Fig. 1.: Left panel showing in situ visceral organs. Right panel showing markedly thickened, multinodular uterine horns occupied almost 35 to 40 % space of abdominal cavity
|  | |
| | Fig. 2.: Left panel: Lungs showing multiple neoplastic nodules randomly scattered on all lobes of lung, whereas unaffected part of lungs showing mild congestion. Right panel: Thoracic wall showing multiple, off white, soft to firm, coalescing, variable sized nodules
|  | |
| | Fig. 3.: Uterus: Moderately cellular neoplasm composed of polygonal cells that arranged in tubules or acini and separated by variably dense fibrovascular stroma. H&E ×50
|  | |
| | Fig. 4.: Higher magnification of Fig. 3. Neoplastic cells have indistinct cell borders, small amount of eosinophilic cytoplasm, round to oval nucleus with finely stippled chromatin, and indistinct nucleoli. H&E ×200.
|  | |
| | Fig. 5.: Lung: Metastasised neoplasm cells arranged in tubules or acini and separated by less dense fibrovascular stroma, whereas unaffected part of lung showing minimal congestion and edema. H&E ×50
|  | |
| | Fig. 6.: Higher magnification of Fig. 5. Note acinar structures lined by cuboidal epithelial cells. H&E ×400
|  | |
| | Fig. 7.: Thoracic wall: Neoplastic cells infiltrated the underlying muscles and arranged in solid sheets or tubules. Underlying rib bones and bone marrow were unaffected. H&E ×50
|  | |
| | Fig. 8.: Higher magnification of Fig. 7. Neoplastic cells with spherical nuclei infiltrating the muscles and arranged in solid sheets. H&E ×200.
|  | |
|
|