In vitro contractile study from excised human gastrointestinal specimens: an important tool for understanding mechanisms of motility disorders Tyagi Preeti1,*, Mandal Maloy B2 1Assistant Professor, Department of Physiology, Hamdard Institute of Medical Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, India 2Professor, Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India *Corresponding Author: Email: drpreetityagi@gmail.com
Online published on 18 December, 2015. Abstract It is well known fact that enteric nervous system plays a major role in regulation of contractile functions of intestinal smooth muscle. A number of neurotransmitters (excitatory/inhibitory) including Acetylcholine (ACh), Histamine, Serotonin, NO, Substance P, Bombesin, Motilin, ATP, VIP, Met-encephalin and Leu-encephalin, Polypeptide Y, Somatostatin are involved in gastrointestinal (GIT) motility mechanism. They are secreted by different neurons of enteric nervous system to modulate contractile and secretory functions of GIT. Dysregulation of some of these transmitters or their receptors have been already implicated in pathophysiology of certain GIT motility disorders. The present paper discusses how an in vitro study on diseased excised specimens may be useful in understanding the pathophysiology of various motility related GIT problems and thereby may be helpful for better medical and surgical management. Top Keywords In vitro study, Gastrointestinal motility, Smooth muscle contraction, Neurotransmitters, Enteric nervous system. Top |