Acute and Sub Acute Toxicity Studies of PavalaParpam Azamthulla Mohammad1,*, Anbu J.2, Murali Anita3 1Assistant Professor, Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054, India 2Professor, Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054, India 3Professor and Head, Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore-560054, India *Corresponding Author E-mail: azamthulla.pg.ph@msruas.ac.in
Online published on 18 January, 2019. Abstract Pavala parpam has long been used as a traditional medicine. In this study, the acute and sub-acute toxicity studies on Pavala parpam were performed in Albino Wistar rats. Limit test (2000mg/kg) was performed to evaluate acute toxicity of Pavala parpam. Sub-acute 28 days toxicity study was carried out at doses 100, 200 and 400 mg/kg. No abnormalities were observed during the 14 days period of acute toxicity study. The biochemical, haematological and physical parameters evaluated during the sub acute toxicity study remained slightly altered compared to the control and histopathological studies revels that liver showed slight inflammatory infiltration, brain showed slight edema, lung shows distend alveoli and congested alveolar wall, kidney showed slight lymphocytic infiltration and pancreas shows atrophic and small congested islets. Hence, the study provides evidence that Pavala parpam is not toxic on acute toxicity and sub acute toxicity studies. Top Keywords Siddha, Acute Toxicity, Pavala Parpam, Sub-Acute Toxicity. Top |