Female reproductive and fetal developmental toxicity upon subchronic intoxication of bisphenol A in Wistar rats Prakash A.1,2,3, Ghosh R.C.2,3, Giri Devesh K.2,3,1,* 2Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Chhattisgarh Kamdhenu Vishwavidyalaya, Anjora, Durg-491001, Chhattisgarh, India; 1Department of Animal Husbandry, Tamilnadu, India; 2Veterinary Polytechnic (CKV, Anjora, Durg), Mahasamund-493445, Chhattisgarh, India *Corresponding author: e-mail: giri.devesh18@gmail.com
Abstract Environmental contaminants can have long lasting effects on fertility. Bisphenol A is an important endocrine disruptor causing potential toxic effects on reproduction of man and animals. The present work deals with the toxic effects of Bisphenol A (BPA) on female reproductive performance and the intrauterine growth and development of rat fetus in three groups, i.e., III, IV and V intoxicated with oral doses of 50, 200 and 600 mg BPA/kg body weight, respectively for 90 days. Group I and II rats served as control and vehicle control, respectively. The reproductive parameters showed reduction in mean uterus weight, litter size/dam, number of corporalutea and implantation site in group V (P≤0.01) and in group IV (≤0.05) as compared to the control groups. The number of live fetus and crown rump length of group IV and V showed dose dependent reduction (P≤0.01) as compared to control group rats. But group V rats alone showed reduction (P≤0.01) in fetal body weight together with an increase (P≤0.01) in number of dead fetuses as compared to all other groups. The developmental toxicity studywas done by double staining protocol using alizarin red and alcian blue which revealed that ratfetusesof group V had maximum number of skeletal abnormalities, like imperfect ossification and deformities in shape as compared to other groups. It is inferred that BPA has toxic potential at higher doses of 200 and 600 mg/kg body weight. Thus, BPA may be considered as one of the important compounds which may influence the reproductive performance of animals. Top Keywords Bisphenol A, Endocrine disruptor, Developmental toxicity, Rats, Reproductive toxicity, Xenoestrogen. Top |