Integrated In-Silico analysis of long non-coding RNAs association with sheep diseases Pandey Aruna3, Saxena Shikha2,3, Ramteke Pramod W.1,3,* 3Department of Computational Biology and Bioinformatics, SHUATS, Allahabad-211007, Uttar Pradesh, India; 1Department of Biological Sciences, SHUATS, Allahabad-211007, Uttar Pradesh, India; 2Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute (IVRI), Izatnagar-243122, Uttar Pradesh, India *Address for Correspondence Dr. Pramod W. Ramteke, Department of Biological Sciences, SHUATS, Allahabad-211007, Uttar Pradesh, India, email: pwramteke@gmail.com
Abstract Long non-coding RNAs (lncRNAs) are mRNA like transcripts longer than 200 nucleotides. They play regulatory roles in several biological processes such as transcriptional regulation, epigenetic modification, development, regulation of immune response. Studies have also shown that many complex human diseases are associated with lncRNAs, database such as lncRNA disease has explored human long non-coding RNAs association with diseases. However, there is very few literature studies reported to pay attention to the study of impact of lncRNAs on livestock diseases. Public repository such as lncRNAdb and ALDB, has only described the status of long non-coding RNAs in livestock species. However, none of these databases focused on sheep lncRNAs information and their association with diseases. In the present study, we proposed that lncRNAs transcripts, derived from sheep genome can be used as a marker for the identification of various disease. The lncRNA transcripts were found closer to sheep disease related genes such as CLCN1 and FGFR3. Several disease-associated microRNAs (miRNAs) such as miR-26b, miR-21 and miR-544 interaction with lncRNA transcripts were also identified. The current research will provide a functional annotation of the sheep genome. The association of lncRNAs with disease-related genes and miRNAs, provides great insight into the underlying pathogenesis of diseases. How to cite this article: Pandey, A, Saxena, S., Ramteke and Pramod W. Integrated In-Silico analysis of long non-coding RNAs association with sheep diseases. (2019). Indian J. Vet. Pathol., 43(3): 177–182. Top Keywords Disease, LncRNAs, MiRNAs, Sheep. Top |