Study of impact of diabetes mellitus on corneal central thickness and endothelial parameters in Indian eyes Shankar C1, Premnath G2,*, Balaji A3, Aila Lakshmi Ananya4, Sruthi G5 1Associate Professor, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India 2Associate Professor, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India 3Professor & HOD, Tagore Medical College & Hospital, Tamil Nadu, India 4Post Graduate, Dept. of Ophthalmology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India 5Post Graduate, Dept. of Ophthalmology, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India *Corresponding Author: Email: drprem1822@gmail.com
Online published on 24 September, 2018. Abstract Aim The purpose of the study is to find the impact of diabetes mellitus on central thickness and endothelial parameters of cornea when compared with non diabetic patients and in relation to duration of disease and glycaemic control Study Design Prospective, Observational and quantitative study Materials and Methods Study included 125 patients (125 eyes) with diabetes mellitus and 143 controls (143 eyes). Tomey specular non-contact microscope (EM 3000) was used to measure central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation of cell size (CV) and percentage of hexagonal endothelial cells (6A) Results Comparison of age matched controls with diabetics did not show any statistical significance with respect to CCT, ECD and CV. 6A showed some significant change (p value= 0.02) between controls and diabetics. There was no significant correlation with respect to the duration of diabetes and glycaemic control Conclusion Corneal endothelial parameters and thickness did not show any statistical significance between diabetics and controls except hexagonality of endothelial cells which was significant. Moreover there was statistically no difference based on duration of the disease, glycaemic control and presence or absence of retinopathy. Top Keywords Central corneal thickness, Endothelial cell density, Diabetes mellitus. Top |