Potential antimalarial activity of polyherbal formulations: A review Aladejana Elizabeth Bosede*, Aladejana Adebowale Emmanuel Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Private Bag X1314, Alice5700, South Africa *Corresponding author e-mail: ealadejana@ufh.ac.za
Online published on 18 January, 2021. Abstract Malaria is a serious life-threatening parasitic disease with major health challenges in tropical and subtropical countries. Despite the significant global efforts in fight against malaria, the emergence and spread of multidrug-resistant strains of Plasmodium to antimalarial medicines have become a recurring problem. Thus, there is an urgent need to search for new effective antimalarial drugs of plant origin that could target both the asexual and sexual stages of the parasites. The present review focused on documenting polyherbal formulations from different continents whose activity against malaria parasite have been reported both in vivo and in vitro clinical experiments. This study compiled several antimalarial polyherbal formulations that serve as a lead for the development of new and effective antiplasmodial drugs, and also reported their activities against different strains of Plasmodium. However, there is a need for the clinical validation of some of these formulations, determination of their mechanism of action, stability, toxicity and identification of the chemical constituents effective in the remedies. Top Keywords Antiplasmodial, Malaria, Polyherbal products, Prophylactics, Suppressive. Top |