Synergistic potential of herbal plants and conventional antibiotics against multidrug-resistant bacteria Onyancha Wilda12, Ali Mohammad Irfan1,*, Sharma Gaurav1, Moin Sarmad1 1School of Applied Sciences, Suresh Gyan Vihar University, Jaipur, Rajasthan, India 2Department of Biological and Biomedical Science and Technology, Laikipia University, 1100-20300, Nyahururu-Kenya *Corresponding author e-mail: irfanclinical.res@gmail.com
Online published on 2 April, 2021. Abstract Multidrug-resistant bacteria strains are a threat globally since they are challenging the use of available conventional antibiotics and hence threatening health sectors globally. The spread of these strains has led to a rising rate in mortality and morbidity. There is an alarming urgent need to discover an alternative natural antimicrobial agent that can has potential bioactive compounds to inhibit the drug-resistant strains. The synergistic potential between herbal plants and conventional antibiotics may render alternative therapy possibilities against multidrug-resistant bacteria strains. Herbal plants have phytochemicals that have shown a promising effect against pathogens causing infection in humans, and have been investigated on their significance to inhibit the survival of pathogenic bacteria. The phytochemicals have also shown the potential to prevent genetic mutation in the organisms besides reversing the muted genetic factor into their initial state hence making them susceptible to the drug. Combination therapy of herbal plants and antibiotics increases its efficacy against the pathogen where it could not be denatured by only conventional strategy. Due to these assertions, synergistic activity should be employed as an alternative therapy strategy against multidrug-resistant microorganisms. Top Keywords Combination therapy, Synergistic potential, Multidrug resistance, Conventional antibiotics. Top |